Recent Publications

Articles

• hTERT DNA Methylation Analysis Identifies a Biomarker for Retinoic Acid-Induced hTERT Repression in Breast Cancer Cell Lines.
  Nguyen E, Richerolle A, Sánchez-Bellver J, Varennes J, Ségal-Bendirdjian E : Biomedicines, 2022
• Obesity II: Establishing causal links between chemical exposures and obesity.
  Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Ji Kim M, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B : Biochem Pharmacol, 2022
• Merging the exposome into an integrated framework for
  Price EJ, Vitale CM, Miller GW, David A, Barouki R, Audouze K, Walker DI, Antignac JP, Coumoul X, Bessonneau V, Klánová J : IScience, 2022
• Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects.
  Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, Schiavi A, Steinwachs S, Esser C, Menzel R, Giani Tagliabue S, Bonati L, Cox F, Ale-Agha N, Jakobs P, Altschmied J, Haendeler J, Coumoul X, Ventura N : Antioxidants (Basel), 2022
• Cytochromes P450 of : Implication in Biological Functions and Metabolism of Xenobiotics.
  Larigot L, Mansuy D, Borowski I, Coumoul X, Dairou J : Biomolecules, 2022
• Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway.
  D’Amico D, Biondi O, Januel C, Bezier C, Sapaly D, Clerc Z, El Khoury M, Sundaram VK, Houdebine L, Josse T, Della Gaspera B, Martinat C, Massaad C, Weill L, Charbonnier F : Neuropathol Appl Neurobiol, 2022
• [Endocrine disruptors : a discussed risk].
  Hill C, Barouki R, Audouze K, Coumoul X : Rev Prat, 2022
• TCDD aggravates the formation of the atherosclerotic plaque in ApoE KO mice with a sexual dimorphic pattern.
  Bey L, Coumoul X, Kim MJ : Biochimie, 2022
• Microbiome and metabolome features of the cardiometabolic disease spectrum.
  Fromentin S, Forslund SK, Chechi K, Aron-Wisnewsky J, Chakaroun R, Nielsen T, Tremaroli V, Ji B, Prifti E, Myridakis A, Chilloux J, Andrikopoulos P, Fan Y, Olanipekun MT, Alves R, Adiouch S, Bar N, Talmor-Barkan Y, Belda E, Caesar R, Coelho LP, Falony G, Fellahi S, Galan P, Galleron N, Helft G, Hoyles L, Isnard R, Le Chatelier E, Julienne H, Olsson L, Pedersen HK, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Schmidt TSB, Vieira-Silva S, Li P, Zimmermann-Kogadeeva M, Lewinter C, Søndertoft NB, Hansen TH, Gauguier D, Gøtze JP, Køber L, Kornowski R, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Letunic I, Bäckhed F, Oppert JM, Nielsen J, Raes J, Bork P, Stumvoll M, Segal E, Clément K, Dumas ME, Ehrlich SD, Pedersen O : Nat Med, 2022
• T cell apoptosis characterizes severe Covid-19 disease.
  André S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butaux A, Soundaramourty C, Cruz AS, Mendes-Frias A, Gotti C, Leclercq M, Nicolas A, Tauzin A, Carvalho A, Capela C, Pedrosa J, Castro AG, Kundura L, Loubet P, Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Racine G, Zghidi-Abouzid O, Nioche P, Silvestre R, Droit A, Mammano F, Corbeau P, Estaquier J : Cell Death Differ, 2022
• [What is known about the action of endocrine disruptors on the immune system?]
  Estaquier J, Blanc É, Coumoul X : Rev Prat, 2021
• Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation.
  Mohammadzadeh N, Roda W, Branton WG, Clain J, Rabezanahary H, Zghidi-Abouzid O, Gelman BB, Angel JB, Cohen EA, Gill MJ, Li M, Estaquier J, Power C : MBio, 2021
• Immune-metabolic interactions between Leishmania and macrophage host.
  Ferreira C, Estaquier J, Silvestre R : Curr Opin Microbiol, 2021
• The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of and Is Not Associated with p47 Phosphorylation.
  Maksouri H, Darif D, Estaquier J, Riyad M, Desterke C, Lemrani M, Dang PM, Akarid K : Microorganisms, 2021
• Mitochondrial Dysfunction as a Hallmark of Environmental Injury.
  Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S : Cells, 2021
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• Development of a chemogenomics library for phenotypic screening.
  Dafniet B, Cerisier N, Boezio B, Clary A, Ducrot P, Dorval T, Gohier A, Brown D, Audouze K, Taboureau O : J Cheminform, 2021
• Development of a chemogenomics library for phenotypic screening.
  Dafniet B, Cerisier N, Boezio B, Clary A, Ducrot P, Dorval T, Gohier A, Brown D, Audouze K, Taboureau O : J Cheminform, 2021
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• The GhsrQ343X allele favors the storage of fat by acting on nutrient partitioning.
  Marion C, Zizzari P, Denis RG, Hassouna R, Chebani Y, Leste-Lasserre T, Doat H, Le Pen G, Cota D, Noble F, Luquet S, Pantel J : J Endocrinol, 2021
• Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex.
  Correia MJ, Pimpão AB, Lopes-Coelho F, Sequeira CO, Coelho NR, Gonçalves-Dias C, Barouki R, Coumoul X, Serpa J, Morello J, Monteiro EC, Pereira SA : Antioxidants (Basel), 2021
• Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor.
  Larigot L, Benoit L, Koual M, Tomkiewicz C, Barouki R, Coumoul X : Annu Rev Pharmacol Toxicol, 2021
• The association between environmental exposures to chlordanes, adiposity and diabetes-related features: a systematic review and meta-analysis.
  Mendes V, Ribeiro C, Delgado I, Peleteiro B, Aggerbeck M, Distel E, Annesi-Maesano I, Sarigiannis D, Ramos E : Sci Rep, 2021
• Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema.
  Margaritte-Jeannin P, Budu-Aggrey A, Ege M, Madore AM, Linhard C, Mohamdi H, von Mutius E, Granell R, Demenais F, Laprise C, Bouzigon E, Dizier MH : Clin Exp Allergy, 2021
• Mechanical loading activates the YAP/TAZ pathway and chemokine expression in the MLO-Y4 osteocyte-like cell line.
  Zarka M, Etienne F, Bourmaud M, Szondi D, Schwartz JM, Kampmann K, Helary C, Rannou F, Haÿ E, Cohen-Solal M : Lab Invest, 2021
• The COVID-19 pandemic and global environmental change: Emerging research needs.
  Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Koskela IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P, HERA-COVID-19 working group Electronic address: https://wwwheraresearcheueu/ : Environ Int, 2021
• Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs.
  Street ME, Audouze K, Legler J, Sone H, Palanza P : Int J Mol Sci, 2021
• Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways.
  Hernandez I, Chissey A, Guibourdenche J, Atasoy R, Coumoul X, Fournier T, Beaudeux JL, Zerrad-Saadi A : Antioxidants (Basel), 2021
• Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged.
  Ahmed S, Salmon H, Distasio N, Do HD, Scherman D, Alhareth K, Tabrizian M, Mignet N : Pharmaceutics, 2021
• Lack of Skeletal Muscle Serotonin Impairs Physical Performance.
  Falabrègue M, Boschat AC, Jouffroy R, Derquennes M, Djemai H, Sanquer S, Barouki R, Coumoul X, Toussaint JF, Hermine O, Noirez P, Côté F : Int J Tryptophan Res, 2021
• Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
  Brial F, Chilloux J, Nielsen T, Vieira-Silva S, Falony G, Andrikopoulos P, Olanipekun M, Hoyles L, Djouadi F, Neves AL, Rodriguez-Martinez A, Mouawad GI, Pons N, Forslund S, Le-Chatelier E, Le Lay A, Nicholson J, Hansen T, Hyötyläinen T, Clément K, Oresic M, Bork P, Ehrlich SD, Raes J, Pedersen OB, Gauguier D, Dumas ME : Gut, 2021
• Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.
  Zgheib E, Kim MJ, Jornod F, Bernal K, Tomkiewicz C, Bortoli S, Coumoul X, Barouki R, De Jesus K, Grignard E, Hubert P, Katsanou ES, Busquet F, Audouze K : Environ Int, 2021
• Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence.
  Matta K, Koual M, Ploteau S, Coumoul X, Audouze K, Le Bizec B, Antignac JP, Cano-Sancho G : Environ Health Perspect, 2021
• RALDH Activity Induced by Bacterial/Fungal Pathogens in CD16 Monocyte-Derived Dendritic Cells Boosts HIV Infection and Outgrowth in CD4 T Cells.
  Cattin A, Wacleche VS, Fonseca Do Rosario N, Marchand LR, Dias J, Gosselin A, Cohen EA, Estaquier J, Chomont N, Routy JP, Ancuta P : J Immunol, 2021
• Differential Inhibition of HIV Replication by the 12 Interferon Alpha Subtypes.
  Tauzin A, Espinosa Ortiz A, Blake O, Soundaramourty C, Joly-Beauparlant C, Nicolas A, Droit A, Dutrieux J, Estaquier J, Mammano F : J Virol, 2021
• Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy.
  Meziane O, Alexandrova Y, Olivenstein R, Dupuy FP, Salahuddin S, Thomson E, Orlova M, Schurr E, Ancuta P, Durand M, Chomont N, Estaquier J, Bernard NF, Costiniuk CT, Jenabian MA : J Immunol, 2021
• Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis.
  Carrete A, Padilla-Ferrer A, Simon A, Meffre D, Jafarian-Tehrani M : Neuroscience, 2021
• Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.
  Calcagnile M, Forgez P, Iannelli A, Bucci C, Alifano M, Alifano P : Biochimie, 2021
• The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response.
  Icard P, Lincet H, Wu Z, Coquerel A, Forgez P, Alifano M, Fournel L : Biochimie, 2021
• AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency.
  Karmouch J, Delers P, Semprez F, Soyed N, Areias J, Bélanger G, Ravel-Chapuis A, Dobbertin A, Jasmin BJ, Legay C : Front Mol Neurosci, 2020
• Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice.
  Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA, Massaad C : Diabetes, 2020
• Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions.
  Russick J, Joubert PE, Gillard-Bocquet M, Torset C, Meylan M, Petitprez F, Dragon-Durey MA, Marmier S, Varthaman A, Josseaume N, Germain C, Goc J, Dieu-Nosjean MC, Validire P, Fournel L, Zitvogel L, Bindea G, Lupo A, Damotte D, Alifano M, Cremer I : J Immunother Cancer, 2020
• Age-dependent vulnerability of the ovary to AhR-mediated TCDD action before puberty: Evidence from mouse models.
  Devillers MM, Petit F, Giton F, François CM, Juricek L, Coumoul X, Magre S, Cohen-Tannoudji J, Guigon CJ : Chemosphere, 2020
• Environmental chemicals, breast cancer progression and drug resistance.
  Koual M, Tomkiewicz C, Cano-Sancho G, Antignac JP, Bats AS, Coumoul X : Environ Health, 2020
• Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.
  Li B, Li Y, Tomkiewicz-Raulet C, Dao P, Lietha D, Yen-Pon E, Du Z, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H : J Med Chem, 2020
• Aging Cartilage in Wild-Type Mice: An Observational Study.
  Akoum J, Tahiri K, Corvol MT, Borderie D, Étienne F, Rannou F, Nguyen C : Cartilage, 2020
• Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.
  Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K : MedRxiv, 2020
• Pathogenesis and therapeutic targets in spinal muscular atrophy (SMA).
  Lefebvre S, Sarret C : Arch Pediatr, 2020
• The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases.
  Sapaly D, Delers P, Coridon J, Salman B, Letourneur F, Dumont F, Lefebvre S : Front Mol Biosci, 2020
• Non-human primates and immunity.
  André S, Rodrigues V, Picard M, Silvestre R, Estaquier J : Cytokine X, 2020
• Cytokines and metabolic regulation: A framework of bidirectional influences affecting Leishmania infection.
  Bodhale N, Ohms M, Ferreira C, Mesquita I, Mukherjee A, André S, Sarkar A, Estaquier J, Laskay T, Saha B, Silvestre R : Cytokine, 2020
• Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
  Rabezanahary H, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Borde C, Mammano F, Mesplèdes T, Ancuta P, Zghidi-Abouzid O, Estaquier J : J Virol, 2020
• Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
  Rabezanahary H, Moukambi F, Palesch D, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Tremblay C, Silvestri G, Estaquier J : Mucosal Immunol, 2020
• Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.
  Ferreira C, Mesquita I, Barbosa AM, Osório NS, Torrado E, Beauparlant CJ, Droit A, Cunha C, Carvalho A, Saha B, Estaquier J, Silvestre R : PLoS Negl Trop Dis, 2020
• The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis.
  Mesquita I, Ferreira C, Moreira D, Kluck GEG, Barbosa AM, Torrado E, Dinis-Oliveira RJ, Gonçalves LG, Beauparlant CJ, Droit A, Berod L, Sparwasser T, Bodhale N, Saha B, Rodrigues F, Cunha C, Carvalho A, Castro AG, Estaquier J, Silvestre R : Cell Rep, 2020
• Antileishmanial Drugs Modulate IL-12 Expression and Inflammasome Activation in Primary Human Cells.
  André S, Rodrigues V, Pemberton S, Laforge M, Fortier Y, Cordeiro-da-Silva A, MacDougall J, Estaquier J : J Immunol, 2020
• Complex context-relationships between DNA methylation and accessibility, histone marks, and hTERT gene expression in acute promyelocytic leukemia cells: perspectives for all-trans retinoic acid (ATRA) in cancer therapy.
  Garsuault D, Bouyer C, Nguyen E, Kandhari R, Prochazkova-Carlotti M, Chevret E, Forgez P, Ségal-Bendirdjian E : Mol Oncol, 2020
• Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants.
  Wu Q, Achebouche R, Audouze K : ALTEX, 2020
• Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.
  Rugard M, Coumoul X, Carvaillo JC, Barouki R, Audouze K : Toxicol Sci, 2020
• Impact of hepatitis C virus and alcohol, alone and combined, on the unfolded protein response in primary human hepatocytes.
  Hernandez C, Blanc EB, Pène V, Le-Grand B, Villaret M, Aoudjehane L, Carpentier A, Conti F, Calmus Y, Podevin P, Garlatti M, Rouach H, Rosenberg AR : Biochimie, 2020
• Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells.
  Bénit P, Kahn A, Chretien D, Bortoli S, Huc L, Schiff M, Gimenez-Roqueplo AP, Favier J, Gressens P, Rak M, Rustin P : PLoS One, 2019
• Mucosal T follicular helper cells in SIV-infected rhesus macaques: contributing role of IL-27.
  Moukambi F, Rabezanahary H, Fortier Y, Rodrigues V, Clain J, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Laforge M, Estaquier J : Mucosal Immunol, 2019
• Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
  Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA : J Virol, 2019
• Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous .
  Rodrigues V, André S, Maksouri H, Mouttaki T, Chiheb S, Riyad M, Akarid K, Estaquier J : Front Cell Infect Microbiol, 2019
• Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform.
  Laliberté-Gagné MÈ, Bolduc M, Thérien A, Garneau C, Casault P, Savard P, Estaquier J, Leclerc D : Vaccines (Basel), 2019
• Serotonin in stem cell based-dental repair and bone formation: A review.
  Baudry A, Schneider B, Launay JM, Kellermann O : Biochimie, 2019
• Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.
  Baudry A, Pietri M, Launay JM, Kellermann O, Schneider B : Front Neurosci, 2019
• Production of seedable Amyloid-β peptides in model of prion diseases upon PrP-induced PDK1 overactivation.
  Ezpeleta J, Baudouin V, Arellano-Anaya ZE, Boudet-Devaud F, Pietri M, Baudry A, Haeberlé AM, Bailly Y, Kellermann O, Launay JM, Schneider B : Nat Commun, 2019
• Effects of Single Cage Housing on Stress, Cognitive, and Seizure Parameters in the Rat and Mouse Pilocarpine Models of Epilepsy.
  Manouze H, Ghestem A, Poillerat V, Bennis M, Ba-M’hamed S, Benoliel JJ, Becker C, Bernard C : ENeuro, 2019
• Preclinical Evaluation of Ga-DOTA-NT-20.3: A Promising PET Imaging Probe To Discriminate Human Pancreatic Ductal Adenocarcinoma from Pancreatitis.
  Prignon A, Provost C, Alshoukr F, Wendum D, Couvelard A, Barbet J, Forgez P, Talbot JN, Gruaz-Guyon A : Mol Pharm, 2019
• Cisplatin increases PD-L1 expression and optimizes immune check-point blockade in non-small cell lung cancer.
  Fournel L, Wu Z, Stadler N, Damotte D, Lococo F, Boulle G, Ségal-Bendirdjian E, Bobbio A, Icard P, Trédaniel J, Alifano M, Forgez P : Cancer Lett, 2019
• sAOP: linking chemical stressors to adverse outcomes pathway networks.
  Aguayo-Orozco A, Audouze K, Siggaard T, Barouki R, Brunak S, Taboureau O : Bioinformatics, 2019
• Applying a Virtual Reality Platform in Environmental Chemistry Education To Conduct a Field Trip to an Overseas Site.
  Blanc E : J Med Chem, 2019
• A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG.
  Leblanc AF, Attignon EA, Distel E, Karakitsios SP, Sarigiannis DA, Bortoli S, Barouki R, Coumoul X, Aggerbeck M, Blanc EB : Environ Res, 2019
• The age-performance relationship in the general population and strategies to delay age related decline in performance.
  Berthelot G, Johnson S, Noirez P, Antero J, Marck A, Desgorces FD, Pifferi F, Carter PA, Spedding M, Manoux AS, Toussaint JF : Arch Public Health, 2019
• KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.
  Goutierre M, Al Awabdh S, Donneger F, François E, Gomez-Dominguez D, Irinopoulou T, Menendez de la Prida L, Poncer JC : Cell Rep, 2019
• Microplastic freshwater contamination: an issue advanced by science with public engagement.
  Allen B, Coumoul X, Lacorte S : Environ Sci Pollut Res Int, 2019
• A forum where french-speaking faculty can exchange research on teaching.
  Vicens Q, Coumoul X, Souciet JL : Biochem Mol Biol Educ, 2019
• Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent.
  Geoffroy H, Canestrelli C, Marie N, Noble F : Int J Neuropsychopharmacol, 2019
• Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.
  Carvaillo JC, Barouki R, Coumoul X, Audouze K : Environ Health Perspect, 2019
• Spontaneous resurgence of conditioned fear weeks after successful extinction in brain injured mice.
  Corne R, Leconte C, Ouradou M, Fassina V, Zhu Y, Déou E, Besson V, Plotkine M, Marchand-Leroux C, Mongeau R : Prog Neuropsychopharmacol Biol Psychiatry, 2019
• Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling.
  Règue M, Poilbout C, Martin V, Franc B, Lanfumey L, Mongeau R : Transl Psychiatry, 2019
• Synchronous Oligometastatic Lung Cancer Deserves a Dedicated Management.
  Loi M, Mazzella A, Mansuet-Lupo A, Bobbio A, Canny E, Magdeleinat P, Régnard JF, Damotte D, Trédaniel J, Alifano M : Ann Thorac Surg, 2019
• Endogenous multidien rhythm of epilepsy in rats.
  Baud MO, Ghestem A, Benoliel JJ, Becker C, Bernard C : Exp Neurol, 2019
• Antioxidant treatment after epileptogenesis onset prevents comorbidities in rats sensitized by a past stressful event.
  Becker C, Mancic A, Ghestem A, Poillerat V, Claverie D, Bartolomei F, Brouillard F, Benoliel JJ, Bernard C : Epilepsia, 2019
• Detection of pretreatment minority HIV-1 reverse transcriptase inhibitor-resistant variants by ultra-deep sequencing has a limited impact on virological outcomes.
  Su B, Zheng X, Liu Y, Liu L, Xin R, Lu H, Huang C, Bai L, Mammano F, Zhang T, Wu H, Sun L, Dai L : J Antimicrob Chemother, 2019
• Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men.
  Jiang L, Audouze K, Romero Herrera JA, Ängquist LH, Kjærulff SK, Izarzugaza JMG, Tjønneland A, Halkjær J, Overvad K, Sørensen TIA, Brunak S : Clin Nutr, 2019
• Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by neurotensin antibody.
  Wu Z, Fournel L, Stadler N, Liu J, Boullier A, Hoyeau N, Fléjou JF, Duchatelle V, Djebrani-Oussedik N, Agopiantz M, Ségal-Bendirdjian E, Gompel A, Alifano M, Melander O, Trédaniel J, Forgez P : Cancer Lett, 2019
• UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects.
  Kuhn E, Lamribet K, Viengchareun S, Le Menuet D, Fève B, Lombès M : Ann Endocrinol (Paris), 2019
• Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression.
  Chen H, Amazit L, Lombès M, Le Menuet D : Neuroscience, 2019
• Behavioral tests that reveal long-term deficits after permanent focal cerebral ischemia in mouse.
  Fréchou M, Margaill I, Marchand-Leroux C, Beray-Berthat V : Behav Brain Res, 2019
• Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families.
  Dizier MH, Margaritte-Jeannin P, Pain L, Sarnowski C, Brossard M, Mohamdi H, Lavielle N, Babron MC, Just J, Lathrop M, Laprise C, Bouzigon E, Demenais F, Nadif R : Thorax, 2019
• Estimating CDKN2A mutation carrier probability among global familial melanoma cases using GenoMELPREDICT.
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• Impact of the HIV integrase genetic context on the phenotypic expression and in vivo emergence of raltegravir resistance mutations.
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• Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture.
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• Cell-to-cell infection by HIV contributes over half of virus infection.
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• Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization.
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• Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi Architecture.
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• Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
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• Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism.
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• Chemical biology databases: from aggregation, curation to representation.
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• Molecular screening of a large cohort of Moroccan patients with congenital hypopituitarism.
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• MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.
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• Essential Roles of Dopamine and Serotonin in Tooth Repair: Functional Interplay Between Odontogenic Stem Cells and Platelets.
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• [Activated platelets help to repair teeth through recruitment of pulpal stem cells].
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• Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation.
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• Health can help saving negotiation on climate change.
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• Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives.
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• Hyperprolinemia in Type 2 Glutaric Aciduria and MADD-Like Profiles.
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• The opioid receptors as targets for drug abuse medication.
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• Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.
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• 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence.
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• Paradoxical resistance to high-fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor-overexpressing mice.
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• The neuronal mineralocorticoid receptor: from cell survival to neurogenesis.
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• Germ cell nuclear factor regulates gametogenesis in developing gonads.
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• Compass: a hybrid method for clinical and biobank data mining.
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• A computational approach to mechanistic and predictive toxicology of pesticides.
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• Applicability of computational systems biology in toxicology.
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• Polychlorinated dibenzo-p-dioxins, furans, and biphenyls (PCDDs/PCDFs and PCBs) in breast milk and early childhood growth and IGF1.
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• Identification of odorant-receptor interactions by global mapping of the human odorome.
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• Proteomic analysis of cAMP-mediated signaling during differentiation of 3 T3-L1 preadipocytes.
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• Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling.
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• Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/β-catenin and Akt/CREB pathways.
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• Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal: comparison with a natural reward.
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• Lipids in metabolic diseases.
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• Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers.
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• A PrP(C)-caveolin-Lyn complex negatively controls neuronal GSK3β and serotonin 1B receptor.
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• [From prion diseases to Alzheimer\\’s disease: a common therapeutic target, PDK1].
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• Pulp stem cells: implication in reparative dentin formation.
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• Lineage stem cell lines: test tubes to build pathophysiological scenarios and discover therapeutic targets.
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• Dual role of the Trps1 transcription factor in dentin mineralization.
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• Plithotaxis, a collective cell migration, regulates the sliding of proliferating pulp cells located in the apical niche.
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• Citrulline induces fatty acid release selectively in visceral adipose tissue from old rats.
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• The burden of osteoarthritis: development and validation of a new assessment tool (BONe\\’S).
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• Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey.
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• Response to Letter to the Editor entitled
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• Inadequate pain relief and large functional loss among patients with knee osteoarthritis: evidence from a prospective multinational longitudinal study of osteoarthritis real-world therapies.
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• Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.
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• Citrulline reduces glyceroneogenesis and induces fatty acid release in visceral adipose tissue from overweight rats.
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• Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case-control study in Guadeloupe (French West Indies).
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• Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites.
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• Influence of cocaine administration patterns on dopamine receptor regulation.
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• Rewarding or aversive effects of buprenorphine/naloxone combination (Suboxone) depend on conditioning trial duration.
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• Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties.
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• Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment.
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• Opioid receptor desensitization: mechanisms and its link to tolerance.
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• High-protein-low-carbohydrate diet: deleterious metabolic and cardiovascular effects depend on age.
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• Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice.
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• Detection of vascular cell adhesion molecule-1 expression with USPIO-enhanced molecular MRI in a mouse model of cerebral ischemia.
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• Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
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• Short-term outcome of patients with preeclampsia.
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• RNA splicing and editing modulation of 5-HT(2C) receptor function: relevance to anxiety and aggression in VGV mice.
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• Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.
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• Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells.
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• A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.
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• Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes.
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• The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis.
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• Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice.
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• Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine.
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• Oculomotor deficits in aryl hydrocarbon receptor null mouse.
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• Early-life prevention of non-communicable diseases
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• A new vesicular scaffolding complex mediates the G-protein-coupled 5-HT1A receptor targeting to neuronal dendrites.
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• Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression.
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• Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures.
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• A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes.
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• A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies.
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• Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.
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• Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia.
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• A novel function for the survival motoneuron protein as a translational regulator.
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• Lithium enhances remyelination of peripheral nerves.
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• Picosecond to second dynamics reveals a structural transition in Clostridium botulinum NO-sensor triggered by the activator BAY-41-2272.
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• Transfer of neuroplasticity from nucleus accumbens core to shell is required for cocaine reward.
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• In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile.
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• Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice.
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• Wnt4 participates in the formation of vertebrate neuromuscular junction
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• The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications.
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• Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants.
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• A head and neck cancer tumor response-specific gene signature for Cisplatin, 5-Fluorouracil induction chemotherapy fails with added taxanes.
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• PPTOX III: Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms.
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• Is there NO help for leptin?
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• Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release
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• Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats.
  Distel E, Penot G, Cadoudal T, Balguy I, Durant S, Benelli C : Biochimie, 2012
• Developmental origins of non-communicable disease: implications for research and public health.
  Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ : Environ Health, 2012
• The aryl hydrocarbon receptor system.
  Barouki R, Aggerbeck M, Aggerbeck L, Coumoul X : Drug Metabol Drug Interact, 2012
• A comparison of two human cell lines and two rat gonadal cell primary cultures as in vitro screening tools for aromatase modulation.
  Quignot N, Desmots S, Barouki R, Lemazurier E : Toxicol In Vitro, 2012
• Lipids in all their states.
  Forest C : Biochimie, 2012
• Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.
  Guyot E, Coumoul X, Chassé JF, Khallouki F, Savouret JF, Poirot M, Barouki R : Biochem Pharmacol, 2012
• Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.
  Kim MJ, Pelloux V, Guyot E, Tordjman J, Bui LC, Chevallier A, Forest C, Benelli C, Clément K, Barouki R : Environ Health Perspect, 2012
• Characterization of endocrine-disrupting chemicals based on hormonal balance disruption in male and female adult rats.
  Quignot N, Arnaud M, Robidel F, Lecomte A, Tournier M, Cren-Olivé C, Barouki R, Lemazurier E : Reprod Toxicol, 2012
• Quantification of steroids and endocrine disrupting chemicals in rat ovaries by LC-MS/MS for reproductive toxicology assessment.
  Quignot N, Tournier M, Pouech C, Cren-Olivé C, Barouki R, Lemazurier E : Anal Bioanal Chem, 2012

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Insulin-like Growth Factors may be Markers of both Traumatic Brain Injury and Fear-Related Stress.

Corne R, Besson V, Ait Si Slimane S, Coutan M, Palhas MLC, Shen FX, Marchand-Leroux C, Ogier M, Mongeau R. Neuroscience. 2021 Jul 1;466:205-221.

 

Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine.

Dallérac G, Li X, Lecouflet P, Morisot N, Sacchi S, Asselot R, Pham TH, Potier B, Watson DJG, Schmidt S, Levasseur G, Fossat P, Besedin A, Rivet JM, Coyle JT, Collo G, Pollegioni L, Kehr J, Galante M, Fone KC, Gardier AM, Freret T, Contarino A, Millan MJ, Mothet JP. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2023750118.

 

Evaluation of Specific Binding of [11C]RTI-97 to Kappa Opioid Receptor by Autoradiography and PET Imaging in Rat.

Fillesoye F, Ibazizène M, Marie N, Noble F, Perrio C. ACS Med Chem Lett. 2021 Oct 19;12(11):1739-1744.

 

Antioxidant Activity and Toxicity Study of Cerium Oxide Nanoparticles Stabilized with Innovative Functional Copolymers.

Goujon G, Baldim V, Roques C, Bia N, Seguin J, Palmier B, Graillot A, Loubat C, Mignet N, Margaill I, Berret JF, Beray-Berthat V. Adv Healthc Mater. 2021 Jun;10(11) ):e2100059.

 

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.

Munn-Chernoff MA, et al. Genetics Working Group (Pantel J) Addict Biol. 2021 Jan;26(1):e12880.

 

Biased Opioid Ligands: Revolution or Evolution?

Noble F, Marie N. Front Pain Res (Lausanne). 2021 Sep 24;2:722820.

 

Effect of Monoclonal Antibody Blockade of Long Fragment Neurotensin on Weight Loss, Behavior, and Metabolic Traits After High-Fat Diet Induced Obesity.

Wu Z, Stadler N, Abbaci A, Liu J, Boullier A, Marie N, Biondi O, Moldes M, Morichon R, Feve B, Melander O, Forgez P. Front Endocrinol (Lausanne). 2021 Oct 8;12:739287.

 

Common Genetic Variation and Age of Onset of Anorexia Nervosa.

Watson HJ, et al., Genetics Working Group (Pantel J) Biol Psychiatry Glob Open Sci. 2021 Sep 20;2(4):368-378.

 

Inhibition of striatal SEZ6 by miR-3594-5p is a drug-specific marker for late-stage heroin intake escalation

Lenoir M., Bondi I., Clemenceau L., Nondier I., Ballé M., Jacques S., Duché A., Saintpierre B., Canestrelli C., Martin-Lannerée S., Mouillet-Richard S., Gunnersen J.M., Ahmed S.H., Marie N., Noble F. (2021) (https://biorxiv.org/cgi/content/short/2021.07.26.453355v1).

 

Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System.

Leconte C, Mongeau R, Noble F. Front Pharmacol. 2022 Apr 27;13:856672.

 

Morphine reduces the interest for natural rewards.

Piccin A, Courtand G, Contarino A. Psychopharmacology (Berl). 2022 Aug;239(8):2407-2419.

 

The CRF1 receptor mediates social behavior deficits induced by opiate withdrawal.

Piccin A, Contarino A. J Neurosci Res. 2022 Jan;100(1):309-321.

 

Activation of the Mu-Delta Opioid Receptor Heteromers Blocks Morphine Rewarding Effects

Requana Aradas A, Djaboub Y, McCort-Tranchepain I, Hajasova Z, Clémenceau L, Canestrelli C, Mann A, Schulz S, Delaval A, Acher F, Massotte D, Noble F, Marie N. Int J Neuropsychopharmacol. 2023 Jul; 26(7): 513–521.

 

Behavioral sensitization to psychostimulants and opioids: What is known in rodents and what still needs to be explored in humans?

Delage C, Morel A, de Witt P, Jauffret-Roustide M, Bloch V, Noble F, Vorspan F, Marie N. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20;127:110824.

 

Oxycodone, an opioid like the others?

Marie N, Noble F. Front Psychiatry. 2023 Dec 13;14:122943.