Recent Publications

Articles

• Pathogenesis and therapeutic targets in spinal muscular atrophy (SMA).
  Lefebvre S, Sarret C : Arch Pediatr, 2020
• The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases.
  Sapaly D, Delers P, Coridon J, Salman B, Letourneur F, Dumont F, Lefebvre S : Front Mol Biosci, 2020
• Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy.
  Sapaly D, Dos Santos M, Delers P, Biondi O, Quérol G, Houdebine L, Khoobarry K, Girardet F, Burlet P, Armand AS, Chanoine C, Bureau JF, Charbonnier F, Lefebvre S : Sci Rep, 2018
• A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.
  Daou N, Lecolle S, Lefebvre S, della Gaspera B, Charbonnier F, Chanoine C, Armand AS : Development, 2013
• A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies.
  Renvoisé B, Quérol G, Verrier ER, Burlet P, Lefebvre S : J Cell Sci, 2012
• Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.
  Piazzon N, Schlotter F, Lefebvre S, Dodré M, Méreau A, Soret J, Besse A, Barkats M, Bordonné R, Branlant C, Massenet S : Nucleic Acids Res, 2012
• The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy.
  Renvoisé B, Colasse S, Burlet P, Viollet L, Meier UT, Lefebvre S : Hum Mol Genet, 2009
• Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells.
  Renvoisé B, Khoobarry K, Gendron MC, Cibert C, Viollet L, Lefebvre S : J Cell Sci, 2006