Recent Publications

Articles

• Mitochondrial Dysfunction as a Hallmark of Environmental Injury.
  Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S : Cells, 2021
• Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor.
  Larigot L, Benoit L, Koual M, Tomkiewicz C, Barouki R, Coumoul X : Annu Rev Pharmacol Toxicol, 2021
• Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.
  Zgheib E, Kim MJ, Jornod F, Bernal K, Tomkiewicz C, Bortoli S, Coumoul X, Barouki R, De Jesus K, Grignard E, Hubert P, Katsanou ES, Busquet F, Audouze K : Environ Int, 2021
• Environmental chemicals, breast cancer progression and drug resistance.
  Koual M, Tomkiewicz C, Cano-Sancho G, Antignac JP, Bats AS, Coumoul X : Environ Health, 2020
• Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.
  Li B, Li Y, Tomkiewicz-Raulet C, Dao P, Lietha D, Yen-Pon E, Du Z, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H : J Med Chem, 2020
• Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.
  Yen-Pon E, Li B, Acebrón-Garcia-de-Eulate M, Tomkiewicz-Raulet C, Dawson J, Lietha D, Frame MC, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H : ACS Chem Biol, 2018
• Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta.
  Wakx A, Nedder M, Tomkiewicz-Raulet C, Dalmasso J, Chissey A, Boland S, Vibert F, Degrelle SA, Fournier T, Coumoul X, Gil S, Ferecatu I : Int J Mol Sci, 2018
• Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration.
  Bui LC, Tomkiewicz C, Pierre S, Chevallier A, Barouki R, Coumoul X : Toxicol Sci, 2015
• Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line.
  Guyot E, Solovyova Y, Tomkiewicz C, Leblanc A, Pierre S, El Balkhi S, Le Frère-Belda MA, Lecuru F, Poupon J, Barouki R, Aggerbeck M, Coumoul X : PLoS One, 2015
• Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.
  Dao P, Smith N, Tomkiewicz-Raulet C, Yen-Pon E, Camacho-Artacho M, Lietha D, Herbeuval JP, Coumoul X, Garbay C, Chen H : J Med Chem, 2014
• A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes.
  Tomkiewicz C, Hans S, Mucchielli MH, Agier N, Delacroix H, Marisa L, Brasnu D, Aggerbeck LP, Badoual C, Barouki R, Aggerbeck M : PLoS One, 2012
• The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway.
  Tomkiewicz C, Herry L, Bui LC, Métayer C, Bourdeloux M, Barouki R, Coumoul X : Oncogene, 2012
• A head and neck cancer tumor response-specific gene signature for Cisplatin, 5-Fluorouracil induction chemotherapy fails with added taxanes.
  Tomkiewicz C, Hans S, Mucchielli MH, Agier N, Delacroix H, Marisa L, Brasnu D, Aggerbeck LP, Badoual C, Barouki R, Aggerbeck M : PLoS One, 2012
• The AhR regulates focal adhesion sites through a non-genomic FAK/Src pathway.
  Tomkiewicz C, Herry L, Bui L-C, Métayer C, Bourdeloux M, Barouki R, Coumoul X : Oncogene, 2012
• Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity
  Bui LC, Tomkiewicz C, Chevallier A, Pierre S, Bats AS, Mota S, Raingeaud J, Pierre J, Diry M, Transy C, Garlatti M, Barouki R, Coumoul X : Oncogene, 2009
• PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.
  Thulin P, Rafter I, Stockling K, Tomkiewicz C, Norjavaara E, Aggerbeck M, Hellmold H, Ehrenborg E, Andersson U, Cotgreave I, Glinghammar B : Toxicol Appl Pharmacol, 2008
• Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione.
  Tordjman J, Leroyer S, Chauvet G, Quette J, Chauvet C, Tomkiewicz C, Chapron C, Barouki R, Forest C, Aggerbeck M, Antoine B : J Biol Chem, 2007
• Neuroprotective effect of mifepristone involves neuron depolarization.
  Ghoumari AM, Piochon C, Tomkiewicz C, Eychenne B, Levenes C, Dusart I, Schumacher M, Baulieu EE : FASEB J, 2006
• Opposite regulation of the rat and human cytosolic aspartate aminotransferase genes by fibrates.
  Tomkiewicz C, Muzeau F, Edgar AD, Barouki R, Aggerbeck M : Biochem Pharmacol, 2004