Recent Publications

Articles

• Obesity II: Establishing causal links between chemical exposures and obesity.
  Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Ji Kim M, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B : Biochem Pharmacol, 2022
• Merging the exposome into an integrated framework for
  Price EJ, Vitale CM, Miller GW, David A, Barouki R, Audouze K, Walker DI, Antignac JP, Coumoul X, Bessonneau V, Klánová J : IScience, 2022
• Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects.
  Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, Schiavi A, Steinwachs S, Esser C, Menzel R, Giani Tagliabue S, Bonati L, Cox F, Ale-Agha N, Jakobs P, Altschmied J, Haendeler J, Coumoul X, Ventura N : Antioxidants (Basel), 2022
• Cytochromes P450 of : Implication in Biological Functions and Metabolism of Xenobiotics.
  Larigot L, Mansuy D, Borowski I, Coumoul X, Dairou J : Biomolecules, 2022
• [Endocrine disruptors : a discussed risk].
  Hill C, Barouki R, Audouze K, Coumoul X : Rev Prat, 2022
• TCDD aggravates the formation of the atherosclerotic plaque in ApoE KO mice with a sexual dimorphic pattern.
  Bey L, Coumoul X, Kim MJ : Biochimie, 2022
• [What is known about the action of endocrine disruptors on the immune system?]
  Estaquier J, Blanc É, Coumoul X : Rev Prat, 2021
• Mitochondrial Dysfunction as a Hallmark of Environmental Injury.
  Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S : Cells, 2021
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex.
  Correia MJ, Pimpão AB, Lopes-Coelho F, Sequeira CO, Coelho NR, Gonçalves-Dias C, Barouki R, Coumoul X, Serpa J, Morello J, Monteiro EC, Pereira SA : Antioxidants (Basel), 2021
• Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor.
  Larigot L, Benoit L, Koual M, Tomkiewicz C, Barouki R, Coumoul X : Annu Rev Pharmacol Toxicol, 2021
• Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways.
  Hernandez I, Chissey A, Guibourdenche J, Atasoy R, Coumoul X, Fournier T, Beaudeux JL, Zerrad-Saadi A : Antioxidants (Basel), 2021
• Lack of Skeletal Muscle Serotonin Impairs Physical Performance.
  Falabrègue M, Boschat AC, Jouffroy R, Derquennes M, Djemai H, Sanquer S, Barouki R, Coumoul X, Toussaint JF, Hermine O, Noirez P, Côté F : Int J Tryptophan Res, 2021
• Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.
  Zgheib E, Kim MJ, Jornod F, Bernal K, Tomkiewicz C, Bortoli S, Coumoul X, Barouki R, De Jesus K, Grignard E, Hubert P, Katsanou ES, Busquet F, Audouze K : Environ Int, 2021
• Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence.
  Matta K, Koual M, Ploteau S, Coumoul X, Audouze K, Le Bizec B, Antignac JP, Cano-Sancho G : Environ Health Perspect, 2021
• Age-dependent vulnerability of the ovary to AhR-mediated TCDD action before puberty: Evidence from mouse models.
  Devillers MM, Petit F, Giton F, François CM, Juricek L, Coumoul X, Magre S, Cohen-Tannoudji J, Guigon CJ : Chemosphere, 2020
• Environmental chemicals, breast cancer progression and drug resistance.
  Koual M, Tomkiewicz C, Cano-Sancho G, Antignac JP, Bats AS, Coumoul X : Environ Health, 2020
• Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.
  Li B, Li Y, Tomkiewicz-Raulet C, Dao P, Lietha D, Yen-Pon E, Du Z, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H : J Med Chem, 2020
• Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.
  Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K : MedRxiv, 2020
• Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.
  Rugard M, Coumoul X, Carvaillo JC, Barouki R, Audouze K : Toxicol Sci, 2020
• A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG.
  Leblanc AF, Attignon EA, Distel E, Karakitsios SP, Sarigiannis DA, Bortoli S, Barouki R, Coumoul X, Aggerbeck M, Blanc EB : Environ Res, 2019
• Microplastic freshwater contamination: an issue advanced by science with public engagement.
  Allen B, Coumoul X, Lacorte S : Environ Sci Pollut Res Int, 2019
• A forum where french-speaking faculty can exchange research on teaching.
  Vicens Q, Coumoul X, Souciet JL : Biochem Mol Biol Educ, 2019
• Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.
  Carvaillo JC, Barouki R, Coumoul X, Audouze K : Environ Health Perspect, 2019
• The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial.
  Coumoul X, Servien R, Juricek L, Kaddouch-Amar Y, Lippi Y, Berthelot L, Naylies C, Morvan ML, Antignac JP, Desdoits-Lethimonier C, Jegou B, Tremblay-Franco M, Canlet C, Debrauwer L, Le Gall C, Laurent J, Gouraud PA, Cravedi JP, Jeunesse E, Savy N, Dandere-Abdoulkarim K, Arnich N, Fourès F, Cotton J, Broudin S, Corman B, Moing A, Laporte B, Richard-Forget F, Barouki R, Rogowsky P, Salles B : Toxicol Sci, 2019
• Associations between exposure to organochlorine chemicals and endometriosis in experimental studies: A systematic review protocol.
  Matta K, Ploteau S, Coumoul X, Koual M, Le Bizec B, Antignac JP, Cano-Sancho G : Environ Int, 2019
• Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.
  Yen-Pon E, Li B, Acebrón-Garcia-de-Eulate M, Tomkiewicz-Raulet C, Dawson J, Lietha D, Frame MC, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H : ACS Chem Biol, 2018
• Integration of the human exposome with the human genome to advance medicine.
  Barouki R, Audouze K, Coumoul X, Demenais F, Gauguier D : Biochimie, 2018
• AhR signaling pathways and regulatory functions.
  Larigot L, Juricek L, Dairou J, Coumoul X : Biochim Open, 2018
• The Aryl Hydrocarbon Receptor and the Nervous System.
  Juricek L, Coumoul X : Int J Mol Sci, 2018
• Rat feeding trials: A comprehensive assessment of contaminants in both genetically modified maize and resulting pellets.
  Chereau S, Rogowsky P, Laporte B, Coumoul X, Moing A, Priymenko N, Steinberg P, Wilhelm R, Schiemann J, Salles B, Richard-Forget F : Food Chem Toxicol, 2018
• Release and toxicity of adipose tissue-stored TCDD: Direct evidence from a xenografted fat model.
  Joffin N, Noirez P, Antignac JP, Kim MJ, Marchand P, Falabregue M, Le Bizec B, Forest C, Emond C, Barouki R, Coumoul X : Environ Int, 2018
• Old Receptor, New Tricks-The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29⁻31 August 2018 in Paris, France.
  Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X : Int J Mol Sci, 2018
• Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta.
  Wakx A, Nedder M, Tomkiewicz-Raulet C, Dalmasso J, Chissey A, Boland S, Vibert F, Degrelle SA, Fournier T, Coumoul X, Gil S, Ferecatu I : Int J Mol Sci, 2018
• Characterization of GMO or glyphosate effects on the composition of maize grain and maize-based diet for rat feeding.
  Bernillon S, Maucourt M, Deborde C, Chéreau S, Jacob D, Priymenko N, Laporte B, Coumoul X, Salles B, Rogowsky PM, Richard-Forget F, Moing A : Metabolomics, 2018
• Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis.
  Shackleford G, Sampathkumar NK, Hichor M, Weill L, Meffre D, Juricek L, Laurendeau I, Chevallier A, Ortonne N, Larousserie F, Herbin M, Bièche I, Coumoul X, Beraneck M, Baulieu EE, Charbonnier F, Pasmant E, Massaad C : Proc Natl Acad Sci U S A, 2018
• Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells.
  Saunier E, Antonio S, Regazzetti A, Auzeil N, Laprévote O, Shay JW, Coumoul X, Barouki R, Benelli C, Huc L, Bortoli S : Sci Rep, 2017
• AhR-deficiency as a cause of demyelinating disease and inflammation.
  Juricek L, Carcaud J, Pelhaitre A, Riday TT, Chevallier A, Lanzini J, Auzeil N, Laprévote O, Dumont F, Jacques S, Letourneur F, Massaad C, Agulhon C, Barouki R, Beraneck M, Coumoul X : Sci Rep, 2017
• Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration.
  Bui LC, Tomkiewicz C, Pierre S, Chevallier A, Barouki R, Coumoul X : Toxicol Sci, 2015
• Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line.
  Guyot E, Solovyova Y, Tomkiewicz C, Leblanc A, Pierre S, El Balkhi S, Le Frère-Belda MA, Lecuru F, Poupon J, Barouki R, Aggerbeck M, Coumoul X : PLoS One, 2015
• Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.
  Dao P, Smith N, Tomkiewicz-Raulet C, Yen-Pon E, Camacho-Artacho M, Lietha D, Herbeuval JP, Coumoul X, Garbay C, Chen H : J Med Chem, 2014
• Citrulline reduces glyceroneogenesis and induces fatty acid release in visceral adipose tissue from overweight rats.
  Joffin N, Jaubert AM, Durant S, Bastin J, De Bandt JP, Cynober L, Moinard C, Coumoul X, Forest C, Noirez P : Mol Nutr Food Res, 2014
• Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case-control study in Guadeloupe (French West Indies).
  Emeville E, Giusti A, Coumoul X, Thomé JP, Blanchet P, Multigner L : Environ Health Perspect, 2014
• Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites.
  Juricek L, Bui LC, Busi F, Pierre S, Guyot E, Lamouri A, Dupret JM, Barouki R, Coumoul X, Rodrigues-Lima F : Arch Toxicol, 2014
• Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin.
  Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui LC, Bats AS, Fournet JC, Fernandez-Salguero P, Aggerbeck M, Lotersztajn S, Barouki R, Coumoul X : Toxicol Sci, 2013
• Oculomotor deficits in aryl hydrocarbon receptor null mouse.
  Chevallier A, Mialot A, Petit JM, Fernandez-Salguero P, Barouki R, Coumoul X, Beraneck M : PLoS One, 2013
• The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway.
  Tomkiewicz C, Herry L, Bui LC, Métayer C, Bourdeloux M, Barouki R, Coumoul X : Oncogene, 2012
• The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications.
  Guyot E, Chevallier A, Barouki R, Coumoul X : Drug Discov Today, 2012
• The AhR regulates focal adhesion sites through a non-genomic FAK/Src pathway.
  Tomkiewicz C, Herry L, Bui L-C, Métayer C, Bourdeloux M, Barouki R, Coumoul X : Oncogene, 2012
• The aryl hydrocarbon receptor system.
  Barouki R, Aggerbeck M, Aggerbeck L, Coumoul X : Drug Metabol Drug Interact, 2012
• Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.
  Guyot E, Coumoul X, Chassé JF, Khallouki F, Savouret JF, Poirot M, Barouki R : Biochem Pharmacol, 2012
• Understanding SOS (Son of Sevenless).
  Pierre S, Bats AS, Coumoul X : Biochem Pharmacol, 2011
• Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.
  Jacob A, Hartz AM, Potin S, Coumoul X, Yousif S, Scherrmann JM, Bauer B, Declèves X : Fluids Barriers CNS, 2011
• NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes.
  Simoni Y, Gautron AS, Beaudoin L, Bui LC, Michel ML, Coumoul X, Eberl G, Leite-de-Moraes M, Lehuen A : Eur J Immunol, 2011
• Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor.
  Barouki R, Coumoul X : Cell Adh Migr, 2010
• Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.
  Fazili IS, Jiang W, Wang L, Felix EA, Khatlani T, Coumoul X, Barouki R, Moorthy B : J Pharmacol Exp Ther, 2010
• 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
  Ambolet-Camoit A, Bui LC, Pierre S, Chevallier A, Marchand A, Coumoul X, Garlatti M, Andreau K, Barouki R, Aggerbeck M : Toxicol Sci, 2010
• Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.
  Blouin JM, Penot G, Collinet M, Nacfer M, Forest C, Laurent-Puig P, Coumoul X, Barouki R, Benelli C, Bortoli S : Int J Cancer, 2010
• BRCA1 affects global DNA methylation through regulation of DNMT1.
  Shukla V, Coumoul X, Lahusen T, Wang RH, Xu X, Vassilopoulos A, Xiao C, Lee MH, Man YG, Ouchi M, Ouchi T, Deng CX : Cell Res, 2010
• Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation.
  Pierre S, Bats AS, Chevallier A, Bui LC, Ambolet-Camoit A, Garlatti M, Aggerbeck M, Barouki R, Coumoul X : Biochem Pharmacol, 2010
• Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity
  Bui LC, Tomkiewicz C, Chevallier A, Pierre S, Bats AS, Mota S, Raingeaud J, Pierre J, Diry M, Transy C, Garlatti M, Barouki R, Coumoul X : Oncogene, 2009
• IGF signaling pathway as a selective target of familial breast cancer therapy.
  Shukla V, Coumoul X, Vassilopoulos A, Deng CX : Curr Mol Med, 2008