Dernières Publications

Articles

• Obesity II: Establishing causal links between chemical exposures and obesity.
  Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Ji Kim M, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B : Biochem Pharmacol, 2022
• Merging the exposome into an integrated framework for
  Price EJ, Vitale CM, Miller GW, David A, Barouki R, Audouze K, Walker DI, Antignac JP, Coumoul X, Bessonneau V, Klánová J : IScience, 2022
• [Endocrine disruptors : a discussed risk].
  Hill C, Barouki R, Audouze K, Coumoul X : Rev Prat, 2022
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex.
  Correia MJ, Pimpão AB, Lopes-Coelho F, Sequeira CO, Coelho NR, Gonçalves-Dias C, Barouki R, Coumoul X, Serpa J, Morello J, Monteiro EC, Pereira SA : Antioxidants (Basel), 2021
• Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor.
  Larigot L, Benoit L, Koual M, Tomkiewicz C, Barouki R, Coumoul X : Annu Rev Pharmacol Toxicol, 2021
• The COVID-19 pandemic and global environmental change: Emerging research needs.
  Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Koskela IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P, HERA-COVID-19 working group Electronic address: https://wwwheraresearcheueu/ : Environ Int, 2021
• Lack of Skeletal Muscle Serotonin Impairs Physical Performance.
  Falabrègue M, Boschat AC, Jouffroy R, Derquennes M, Djemai H, Sanquer S, Barouki R, Coumoul X, Toussaint JF, Hermine O, Noirez P, Côté F : Int J Tryptophan Res, 2021
• Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.
  Zgheib E, Kim MJ, Jornod F, Bernal K, Tomkiewicz C, Bortoli S, Coumoul X, Barouki R, De Jesus K, Grignard E, Hubert P, Katsanou ES, Busquet F, Audouze K : Environ Int, 2021
• Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.
  Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K : MedRxiv, 2020
• Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.
  Rugard M, Coumoul X, Carvaillo JC, Barouki R, Audouze K : Toxicol Sci, 2020
• sAOP: linking chemical stressors to adverse outcomes pathway networks.
  Aguayo-Orozco A, Audouze K, Siggaard T, Barouki R, Brunak S, Taboureau O : Bioinformatics, 2019
• A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG.
  Leblanc AF, Attignon EA, Distel E, Karakitsios SP, Sarigiannis DA, Bortoli S, Barouki R, Coumoul X, Aggerbeck M, Blanc EB : Environ Res, 2019
• Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.
  Carvaillo JC, Barouki R, Coumoul X, Audouze K : Environ Health Perspect, 2019
• Determination of bisphenol A and bisphenol S concentrations and assessment of estrogen- and anti-androgen-like activities in thermal paper receipts from Brazil, France, and Spain.
  Molina-Molina JM, Jiménez-Díaz I, Fernández MF, Rodriguez-Carrillo A, Peinado FM, Mustieles V, Barouki R, Piccoli C, Olea N, Freire C : Environ Res, 2019
• The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial.
  Coumoul X, Servien R, Juricek L, Kaddouch-Amar Y, Lippi Y, Berthelot L, Naylies C, Morvan ML, Antignac JP, Desdoits-Lethimonier C, Jegou B, Tremblay-Franco M, Canlet C, Debrauwer L, Le Gall C, Laurent J, Gouraud PA, Cravedi JP, Jeunesse E, Savy N, Dandere-Abdoulkarim K, Arnich N, Fourès F, Cotton J, Broudin S, Corman B, Moing A, Laporte B, Richard-Forget F, Barouki R, Rogowsky P, Salles B : Toxicol Sci, 2019
• The 9th Santorini Conference: Systems Medicine, Personalised Health and Therapy.
  Visvikis-Siest S, Gorenjak V, Stathopoulou MG, Petrelis AM, Weryha G, Masson C, Hiegel B, Kumar S, Barouki R, Boerwinkle E, Dagher G, Deloukas P, Innocenti F, Lamont J, Marschler M, Meyer H, Meyer UA, Nofziger C, Paulmichl M, Vacher C, Webster L : J Pers Med, 2018
• [Endocrine disruptor compounds and new mechanisms of toxicity networks].
  Barouki R : Rev Prat, 2018
• Integration of the human exposome with the human genome to advance medicine.
  Barouki R, Audouze K, Coumoul X, Demenais F, Gauguier D : Biochimie, 2018
• Release and toxicity of adipose tissue-stored TCDD: Direct evidence from a xenografted fat model.
  Joffin N, Noirez P, Antignac JP, Kim MJ, Marchand P, Falabregue M, Le Bizec B, Forest C, Emond C, Barouki R, Coumoul X : Environ Int, 2018
• Old Receptor, New Tricks-The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29⁻31 August 2018 in Paris, France.
  Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X : Int J Mol Sci, 2018
• Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
  Barouki R, Melén E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K : Environ Int, 2018
• Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells.
  Saunier E, Antonio S, Regazzetti A, Auzeil N, Laprévote O, Shay JW, Coumoul X, Barouki R, Benelli C, Huc L, Bortoli S : Sci Rep, 2017
• Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells.
  Attignon EA, Distel E, Le-Grand B, Leblanc AF, Barouki R, de Oliveira E, Aggerbeck M, Blanc EB : Toxicol In Vitro, 2017
• AhR-deficiency as a cause of demyelinating disease and inflammation.
  Juricek L, Carcaud J, Pelhaitre A, Riday TT, Chevallier A, Lanzini J, Auzeil N, Laprévote O, Dumont F, Jacques S, Letourneur F, Massaad C, Agulhon C, Barouki R, Beraneck M, Coumoul X : Sci Rep, 2017
• Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration.
  Bui LC, Tomkiewicz C, Pierre S, Chevallier A, Barouki R, Coumoul X : Toxicol Sci, 2015
• Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line.
  Guyot E, Solovyova Y, Tomkiewicz C, Leblanc A, Pierre S, El Balkhi S, Le Frère-Belda MA, Lecuru F, Poupon J, Barouki R, Aggerbeck M, Coumoul X : PLoS One, 2015
• Long-term outcomes in Ornithine Transcarbamylase deficiency: a series of 90 patients.
  Brassier A, Gobin S, Arnoux JB, Valayannopoulos V, Habarou F, Kossorotoff M, Servais A, Barbier V, Dubois S, Touati G, Barouki R, Lesage F, Dupic L, Bonnefont JP, Ottolenghi C, De Lonlay P : Orphanet J Rare Dis, 2015
• Contiguous mutation syndrome in the era of high-throughput sequencing.
  Langouët M, Siquier-Pernet K, Sanquer S, Bole-Feysot C, Nitschke P, Boddaert N, Munnich A, Mancini GM, Barouki R, Amiel J, Colleaux L : Mol Genet Genomic Med, 2015
• A generic methodological framework for studying single cell motility in high-throughput time-lapse data.
  Schoenauer Sebag A, Plancade S, Raulet-Tomkiewicz C, Barouki R, Vert JP, Walter T : Bioinformatics, 2015
• Health can help saving negotiation on climate change.
  Flahault A, Schütte S, Guégan JF, Pascal M, Barouki R : Lancet, 2015
• Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism.
  Ambolet-Camoit A, Ottolenghi C, Leblanc A, Kim MJ, Letourneur F, Jacques S, Cagnard N, Guguen-Guillouzo C, Barouki R, Aggerbeck M : Biochimie, 2015
• Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats.
  Joffin N, Jaubert AM, Bamba J, Barouki R, Noirez P, Forest C : Adipocyte, 2015
• Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives.
  Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ : Endocrinology, 2015
• Hyperprolinemia in Type 2 Glutaric Aciduria and MADD-Like Profiles.
  Pontoizeau C, Habarou F, Brassier A, Veauville-Merllié A, Grisel C, Arnoux JB, Vianey-Saban C, Barouki R, Chadefaux-Vekemans B, Acquaviva C, de Lonlay P, Ottolenghi C : JIMD Rep, 2015
• Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites.
  Juricek L, Bui LC, Busi F, Pierre S, Guyot E, Lamouri A, Dupret JM, Barouki R, Coumoul X, Rodrigues-Lima F : Arch Toxicol, 2014
• Early-life prevention of non-communicable diseases.
  Balbus JM, Barouki R, Birnbaum LS, Etzel RA, Gluckman PD, Grandjean P, Hancock C, Hanson MA, Heindel JJ, Hoffman K, Jensen GK, Keeling A, Neira M, Rabadán-Diehl C, Ralston J, Tang KC : Lancet, 2013
• [Environment and health: the lessons of pesticides].
  Barouki R : Med Sci (Paris), 2013
• [Can xenobiotics accumulated in adipose tissue contribute to a carcinogenic risk?].
  Barouki R : Ann Endocrinol (Paris), 2013
• Viewing drug action as network perturbation in multiple scale systems.
  Barouki R : Drug Metabol Drug Interact, 2013
• Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin.
  Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui LC, Bats AS, Fournet JC, Fernandez-Salguero P, Aggerbeck M, Lotersztajn S, Barouki R, Coumoul X : Toxicol Sci, 2013
• Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.
  Janin M, Mylonas E, Saada V, Micol JB, Renneville A, Quivoron C, Koscielny S, Scourzic L, Forget S, Pautas C, Caillot D, Preudhomme C, Dombret H, Berthon C, Barouki R, Rabier D, Auger N, Griscelli F, Chachaty E, Leclercq E, Courtier MH, Bennaceur-Griscelli A, Solary E, Bernard OA, Penard-Lacronique V, Ottolenghi C, de Botton S : J Clin Oncol, 2013
• Oculomotor deficits in aryl hydrocarbon receptor null mouse.
  Chevallier A, Mialot A, Petit JM, Fernandez-Salguero P, Barouki R, Coumoul X, Beraneck M : PLoS One, 2013
• Expression of calcineurin activity after lung transplantation: a 2-year follow-up.
  Sanquer S, Amrein C, Grenet D, Guillemain R, Philippe B, Boussaud V, Herry L, Lena C, Diouf A, Paunet M, Billaud EM, Loriaux F, Jais JP, Barouki R, Stern M : PLoS One, 2013
• Early-life prevention of non-communicable diseases
  Balbus JM, Barouki R, Birnbaum LS, Etzel RA, Gluckman PD, Grandjean P, Hancock C, Hanson MA, Heindel JJ, Hoffman K, Jensen G, Keeling A, Neira M, Rabadan-Diehl C, Ralston J, Tang KC : Lancet, 2013
• A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes.
  Tomkiewicz C, Hans S, Mucchielli MH, Agier N, Delacroix H, Marisa L, Brasnu D, Aggerbeck LP, Badoual C, Barouki R, Aggerbeck M : PLoS One, 2012
• The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway.
  Tomkiewicz C, Herry L, Bui LC, Métayer C, Bourdeloux M, Barouki R, Coumoul X : Oncogene, 2012
• PPTOX III: environmental stressors in the developmental origins of disease--evidence and mechanisms.
  Schug TT, Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ : Toxicol Sci, 2012
• The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications.
  Guyot E, Chevallier A, Barouki R, Coumoul X : Drug Discov Today, 2012
• Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants.
  La Merrill M, Emond C, Kim MJ, Antignac JP, Le Bizec B, Clément K, Birnbaum LS, Barouki R : Environ Health Perspect, 2012
• A head and neck cancer tumor response-specific gene signature for Cisplatin, 5-Fluorouracil induction chemotherapy fails with added taxanes.
  Tomkiewicz C, Hans S, Mucchielli MH, Agier N, Delacroix H, Marisa L, Brasnu D, Aggerbeck LP, Badoual C, Barouki R, Aggerbeck M : PLoS One, 2012
• The AhR regulates focal adhesion sites through a non-genomic FAK/Src pathway.
  Tomkiewicz C, Herry L, Bui L-C, Métayer C, Bourdeloux M, Barouki R, Coumoul X : Oncogene, 2012
• PPTOX III: Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms.
  Schug TT, Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ : Toxicol Sci, 2012
• Developmental origins of non-communicable disease: implications for research and public health.
  Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ : Environ Health, 2012
• The aryl hydrocarbon receptor system.
  Barouki R, Aggerbeck M, Aggerbeck L, Coumoul X : Drug Metabol Drug Interact, 2012
• A comparison of two human cell lines and two rat gonadal cell primary cultures as in vitro screening tools for aromatase modulation.
  Quignot N, Desmots S, Barouki R, Lemazurier E : Toxicol In Vitro, 2012
• Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.
  Guyot E, Coumoul X, Chassé JF, Khallouki F, Savouret JF, Poirot M, Barouki R : Biochem Pharmacol, 2012
• Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.
  Kim MJ, Pelloux V, Guyot E, Tordjman J, Bui LC, Chevallier A, Forest C, Benelli C, Clément K, Barouki R : Environ Health Perspect, 2012
• Characterization of endocrine-disrupting chemicals based on hormonal balance disruption in male and female adult rats.
  Quignot N, Arnaud M, Robidel F, Lecomte A, Tournier M, Cren-Olivé C, Barouki R, Lemazurier E : Reprod Toxicol, 2012
• Quantification of steroids and endocrine disrupting chemicals in rat ovaries by LC-MS/MS for reproductive toxicology assessment.
  Quignot N, Tournier M, Pouech C, Cren-Olivé C, Barouki R, Lemazurier E : Anal Bioanal Chem, 2012
• ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes.
  Magne L, Blanc E, Legrand B, Lucas D, Barouki R, Rouach H, Garlatti M : J Hepatol, 2011
• Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss.
  Kim MJ, Marchand P, Henegar C, Antignac JP, Alili R, Poitou C, Bouillot JL, Basdevant A, Le Bizec B, Barouki R, Clément K : Environ Health Perspect, 2011
• Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor.
  Barouki R, Coumoul X : Cell Adh Migr, 2010
• Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.
  Fazili IS, Jiang W, Wang L, Felix EA, Khatlani T, Coumoul X, Barouki R, Moorthy B : J Pharmacol Exp Ther, 2010
• 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
  Ambolet-Camoit A, Bui LC, Pierre S, Chevallier A, Marchand A, Coumoul X, Garlatti M, Andreau K, Barouki R, Aggerbeck M : Toxicol Sci, 2010
• Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.
  Blouin JM, Penot G, Collinet M, Nacfer M, Forest C, Laurent-Puig P, Coumoul X, Barouki R, Benelli C, Bortoli S : Int J Cancer, 2010
• Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation.
  Pierre S, Bats AS, Chevallier A, Bui LC, Ambolet-Camoit A, Garlatti M, Aggerbeck M, Barouki R, Coumoul X : Biochem Pharmacol, 2010
• Characterisation of a human liver cystathionine beta synthase mRNA sequence corresponding to the c.[833T>C;844_845ins68] mutation in CBS gene.
  Chassé JF, Barouki R : Mol Cell Biochem, 2009
• Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity
  Bui LC, Tomkiewicz C, Chevallier A, Pierre S, Bats AS, Mota S, Raingeaud J, Pierre J, Diry M, Transy C, Garlatti M, Barouki R, Coumoul X : Oncogene, 2009
• Hypoxia down-regulates CCAAT/enhancer binding protein-alpha expression in breast cancer cells.
  Seifeddine R, Dreiem A, Blanc E, Fulchignoni-Lataud MC, Le Frère Belda MA, Lecuru F, Mayi TH, Mazure N, Favaudon V, Massaad C, Barouki R, Massaad-Massade L : Cancer Res, 2008
• Stabilization of IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway.
  Magne L, Blanc E, Marchand A, Fafournoux P, Barouki R, Rouach H, Garlatti M : J Hepatol, 2007
• Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione.
  Tordjman J, Leroyer S, Chauvet G, Quette J, Chauvet C, Tomkiewicz C, Chapron C, Barouki R, Forest C, Aggerbeck M, Antoine B : J Biol Chem, 2007
• Cholesteryl ester hydroperoxides increase macrophage CD36 gene expression via PPARalpha.
  Jedidi I, Couturier M, Thérond P, Gardès-Albert M, Legrand A, Barouki R, Bonnefont-Rousselot D, Aggerbeck M : Biochem Biophys Res Commun, 2006
• Opposite regulation of the rat and human cytosolic aspartate aminotransferase genes by fibrates.
  Tomkiewicz C, Muzeau F, Edgar AD, Barouki R, Aggerbeck M : Biochem Pharmacol, 2004
• Determination of interleukin-4-responsive region in the human cytochrome P450 2E1 gene promoter.
  Abdel-Razzak Z, Garlatti M, Aggerbeck M, Barouki R : Biochem Pharmacol, 2004
• Mouse liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia.
  Janel N, Robert K, Chabert C, Ledru A, Gouédard C, Barouki R, Delabar JM, Chassé JF : Thromb Haemost, 2004